Prolonged non-coding RNA CRNDE suppressing cell proliferation is regulated by DNA methylation in continuous lymphocytic leukemia
Prolonged non-coding RNA CRNDE and DNA methylation play a major place inside the prevalence and enchancment of continuous lymphocytic leukemia (CLL). This study tried to analysis the natural place of CRNDE methylation in CLL. The expression and methylation ranges of CRNDE in CLL cell traces (MEC-1 and HG3) sooner than or after methylation inhibitor (5-Aza-2′-deoxycytidine, 5-Aza-CdR) remedy was detected by quantitative real-time PCR or methylation-Explicit PCR.
The connection amongst CRNDE, miR-28 and NDRG2 was verified by luciferase reporter assay. The influence of CRNDE overexpression and 5-Aza-CdR remedy on cell proliferation and apoptosis of MEC-1 and HG3 cells had been assessed by CCK8 and stream cytomery. In distinction with common B lymphocytes, CRNDE was down-regulated and the methylation diploma of CRNDE was elevated in MEC-1 and HG3 cells. Then, 5-Aza-CdR remedy induced an increase of CRNDE expression in MEC-1 and HG3 cells by demethylation.
The overexpression or demethylation of CRNDE inhibited cell proliferation and promoted apoptosis in MEC-1 and HG3 cells by up-regulating CRNDE expression. Moreover, CRNDE functioned as a competing endogenous RNA to repress miR-28, which managed its down-stream purpose NDRG2. CRNDE overexpression inhibited cell proliferation and promoted apoptosis by the use of miR-28/NDRG2 axis in CLL.
In conclusion, our data elaborated that CRNDE expression was regulated by DNA methylation, and the protective influence of CRNDE on CLL was attributed to the inhibition of proliferation in CLL by the use of miR-28/NDRG2 axis. Thus, this work highlights a novel competing endogenous RNA circuitry involving key regulators of CLL.
nexgentek
 IL-2 Receptor ?, Human Recombinant |
|
7100-10 |
Biovision |
|
EUR 196 |
IL-2 Receptor ?, Human Recombinant |
|
7100-50 |
Biovision |
|
EUR 637 |
 Human CellExp? IL-4 R?, Human Recombinant |
|
7101-10 |
Biovision |
|
EUR 229 |
Human CellExp? IL-4 R?, Human Recombinant |
|
7101-50 |
Biovision |
|
EUR 881 |
 Human CellExp? IL-6 R?, Human Recombinant |
|
7102-10 |
Biovision |
|
EUR 207 |
Human CellExp? IL-6 R?, Human Recombinant |
|
7102-50 |
Biovision |
|
EUR 800 |
 IL-9, Rat Recombinant |
|
7103-10 |
Biovision |
|
EUR 278 |
IL-9, Rat Recombinant |
|
7103-50 |
Biovision |
|
EUR 1132 |
 IL-12p80, Human Recombinant |
|
7104-10 |
Biovision |
|
EUR 392 |
IL-12p80, Human Recombinant |
|
7104-50 |
Biovision |
|
EUR 1675 |
 IL-17A, Mouse Recombinant |
|
7105-10 |
Biovision |
|
EUR 196 |
IL-17A, Mouse Recombinant |
|
7105-50 |
Biovision |
|
EUR 675 |
 IL-17B, Human Recombinant |
|
7106-10 |
Biovision |
|
EUR 196 |
IL-17B, Human Recombinant |
|
7106-50 |
Biovision |
|
EUR 675 |
 IL-17D, Human Recombinant |
|
7107-10 |
Biovision |
|
EUR 196 |
IL-17D, Human Recombinant |
|
7107-50 |
Biovision |
|
EUR 675 |
 Human CellExp? IL-34, Human Recombinant |
|
7108-10 |
Biovision |
|
EUR 278 |
Human CellExp? IL-34, Human Recombinant |
|
7108-50 |
Biovision |
|
EUR 1132 |
 IL-36RA, Human Recombinant |
|
7109-10 |
Biovision |
|
EUR 196 |
IL-36RA, Human Recombinant |
|
7109-50 |
Biovision |
|
EUR 675 |
 IL-36?, Human Recombinant |
|
7110-10 |
Biovision |
|
EUR 278 |
IL-36?, Human Recombinant |
|
7110-50 |
Biovision |
|
EUR 1132 |
IL-36?, Human Recombinant |
|
7111-10 |
Biovision |
|
EUR 278 |
IL-36?, Human Recombinant |
|
7111-50 |
Biovision |
|
EUR 1132 |
 Activin B, Human Recombinant |
|
7112-10 |
Biovision |
|
EUR 479 |
Activin B, Human Recombinant |
|
7112-50 |
Biovision |
|
EUR 2094 |
 AITRL, Human Recombinant |
|
7113-10 |
Biovision |
|
EUR 251 |
AITRL, Human Recombinant |
|
7113-50 |
Biovision |
|
EUR 936 |
 Amphiregulin, Human Recombinant |
|
7114-10 |
Biovision |
|
EUR 147 |
Amphiregulin, Human Recombinant |
|
7114-50 |
Biovision |
|
EUR 376 |
 ANG-1, Human Recombinant |
|
7115-10 |
Biovision |
|
EUR 251 |
ANG-1, Human Recombinant |
|
7115-50 |
Biovision |
|
EUR 936 |
 ANG-2, Human Recombinant |
|
7116-10 |
Biovision |
|
EUR 251 |
ANG-2, Human Recombinant |
|
7116-50 |
Biovision |
|
EUR 936 |
 APRIL, Human Recombinant |
|
7117-10 |
Biovision |
|
EUR 311 |
APRIL, Human Recombinant |
|
7117-50 |
Biovision |
|
EUR 1300 |
 APRIL, Mouse Recombinant |
|
7118-10 |
Biovision |
|
EUR 196 |
APRIL, Mouse Recombinant |
|
7118-50 |
Biovision |
|
EUR 675 |
 Betacellulin, Murine Recombinant |
|
7119-10 |
Biovision |
|
EUR 196 |
Betacellulin, Murine Recombinant |
|
7119-50 |
Biovision |
|
EUR 675 |
 Cardiotrophin-1, Murine Recombinant |
|
7121-10 |
Biovision |
|
EUR 278 |
Cardiotrophin-1, Murine Recombinant |
|
7121-50 |
Biovision |
|
EUR 1132 |
 sCD100/Semaphorin-4D, Human Recombinant |
|
7126-10 |
Biovision |
|
EUR 251 |
sCD100/Semaphorin-4D, Human Recombinant |
|
7126-50 |
Biovision |
|
EUR 936 |
 CTGFL/WISP-2, Human Recombinant |
|
7129-10 |
Biovision |
|
EUR 234 |
CTGFL/WISP-2, Human Recombinant |
|
7129-50 |
Biovision |
|
EUR 860 |
 Human CellExp? DKK-1, Human Recombinant |
|
7132-10 |
Biovision |
|
EUR 278 |
Human CellExp? DKK-1, Human Recombinant |
|
7132-50 |
Biovision |
|
EUR 1132 |
 Human CellExp? sDLL-1, Human Recombinant |
|
7133-10 |
Biovision |
|
EUR 207 |
Human CellExp? sDLL-1, Human Recombinant |
|
7133-50 |
Biovision |
|
EUR 675 |
 Human CellExp? sDLL-4, Human Recombinant |
|
7134-10 |
Biovision |
|
EUR 207 |
Human CellExp? sDLL-4, Human Recombinant |
|
7134-50 |
Biovision |
|
EUR 675 |
 Eotaxin-2/CCL24, murine recombinant |
|
7137-10 |
Biovision |
|
EUR 207 |
Eotaxin-2/CCL24, murine recombinant |
|
7137-50 |
Biovision |
|
EUR 675 |
 Eotaxin-3/CCL26, human recombinant |
|
7138-10 |
Biovision |
|
EUR 207 |
Eotaxin-3/CCL26, human recombinant |
|
7138-50 |
Biovision |
|
EUR 675 |
 Human CellExp? Fetuin A/ASHG, Human Recombinant |
|
7142-10 |
Biovision |
|
EUR 153 |
Human CellExp? Fetuin A/ASHG, Human Recombinant |
|
7142-50 |
Biovision |
|
EUR 381 |
 Histone H3 Peptide, biotin conjugate |
|
7143-01 |
Biovision |
|
EUR 240 |
Histone H3 Peptide, biotin conjugate |
|
7143-1 |
Biovision |
|
EUR 1132 |
 Histone H4 Peptide, tetra-acetylated, biotin conjugate |
|
7144-01 |
Biovision |
|
EUR 240 |
Histone H4 Peptide, tetra-acetylated, biotin conjugate |
|
7144-1 |
Biovision |
|
EUR 1132 |
 FGF-5, human recombinant |
|
7147-10 |
Biovision |
|
EUR 142 |
FGF-5, human recombinant |
|
7147-50 |
Biovision |
|
EUR 359 |
 FGF-6, human recombinant |
|
7148-10 |
Biovision |
|
EUR 207 |
FGF-6, human recombinant |
|
7148-50 |
Biovision |
|
EUR 675 |
 FGF-16, human recombinant |
|
7149-10 |
Biovision |
|
EUR 207 |
FGF-16, human recombinant |
|
7149-50 |
Biovision |
|
EUR 675 |
 FGF-17, human recombinant |
|
7150-10 |
Biovision |
|
EUR 207 |
Secondary structural various of DNA and RNA associated to CGG/CCG trinucleotide repeat enlargement rationalizes the RNA misprocessing in FXTAS
CGG tandem repeat enlargement inside the 5′-untranslated space of the fragile X psychological retardation-1 (FMR1) gene ends in unusual nucleic acid conformations, due to this fact inflicting genetic instabilities. We current that the number of G…G (in CGG repeat) or C…C (in CCG repeat) mismatches (apart from A…T, T…A, C…G and G…C canonical base pairs) dictates the secondary structural various of the sense and antisense strands of the FMR1 gene and their corresponding transcripts in fragile X-associated tremor/ataxia syndrome (FXTAS).
The spherical dichroism (CD) spectra and electrophoretic mobility shift assay (EMSA) reveal that CGG DNA (sense strand of the FMR1 gene) and its transcript favor a quadruplex development. CD, EMSA and molecular dynamics (MD) simulations moreover current that further than four C…C mismatches cannot be accommodated inside the RNA duplex consisting of the CCG repeat (antisense transcript); as an alternative, it favors an i-motif conformational intermediate.
Such a alternative for unusual secondary constructions provides a convincing justification for the RNA foci formation due to the sequestration of RNA-binding proteins to the bidirectional transcripts and the repeat-associated non-AUG translation that are seen in FXTAS. The outcomes launched proper right here moreover advocate that small molecule modulators which will destabilize FMR1 CGG DNA and RNA quadruplex constructions might probably be promising candidates for treating FXTAS.
A protracted intergenic non-coding RNA regulates nuclear localization of DNA methyl transferase-1
DNA methyl transferase-1 or DNMT1 maintains DNA methylation inside the genome and is important for regulating gene expression in cells. Aberrant changes in DNMT1 train and DNA methylation are typically seen in cancers and loads of completely different illnesses. Simply currently, a variety of prolonged intergenic non-protein-coding RNAs or lincRNAs have been confirmed to play a job in regulating DNMT1 train. CCDC26 is a nuclear lincRNA that is steadily mutated in cancers and is a hotbed for disease-associated single nucleotide changes.
Nonetheless, the sensible mechanism of CCDC26 is simply not understood. Proper right here, we current that this lincRNA is focusing on the nuclear periphery. Strikingly, inside the absence of CCDC26 lincRNA, DNMT1 is mis-located inside the cytoplasm, and the genomic DNA is significantly hypomethylated. That’s accompanied by double-stranded DNA breaks and elevated cell dying. These outcomes stage to a beforehand unrecognized mechanism of lincRNA-mediated subcellular localization of DNMT1 and regulation of DNA methylation.
Environmental DNA and environmental RNA: Current and potential functions for natural monitoring
Standard environmental biomonitoring approaches have limitations in relation to species detectability and their functionality to account for spatial and temporal variation. Furthermore, as invasive strategies they’re typically harmful to explicit particular person organisms, populations and habitats. The equipment of non-invasive sampling methods that extract, isolate and set up nucleic acid sequences (i.e. DNA, RNA) from environmental matrices have very important potential for complementing, and even ultimately altering, current methods of natural environmental analysis.
These environmental DNA (eDNA) and environmental RNA (eRNA) strategies improve spatial and temporal acuity of monitoring, and inside the case of the latter, might current sensible knowledge regarding the nicely being of individuals, and thus ecosystems. Nonetheless, these assessments require robust analysis of issues such as a result of the detectability and specificity of the developed assays.
The launched work highlights the current and future makes use of of nucleic acid-based biomonitoring regimes, with a take care of fish and aquatic invertebrates and their utility for water prime quality, biodiversity and species-specific monitoring. These strategies are compared with typical approaches, with a selected emphasis on the potential insights that might probably be equipped by eRNA analysis, along with some great benefits of microRNAs as assay targets.
Extreme-throughput label-free detection of DNA-to-RNA transcription inhibition using brightfield microscopy and deep neural networks
Drug discovery is in mounted evolution and foremost advances have led to the occasion of in vitro high-throughput utilized sciences, facilitating the quick analysis of cell phenotypes. One such phenotype is immunogenic cell dying, which occurs partly as a consequence of inhibited RNA synthesis. Automated cell-imaging supplies the potential for combining high-throughput with high-content data acquisition by the simultaneous computation of numerous cell choices. Usually, such choices are extracted from fluorescence pictures, due to this fact requiring labeling of the cells using dyes with attainable cytotoxic and phototoxic destructive results.
Simply currently, deep learning approaches have allowed the analysis of pictures obtained by brightfield microscopy, a manner that was for prolonged underexploited, with the great good thing about avoiding any foremost interference with cell physiology or stimulatory compounds. Proper right here, we describe a label-free image-based high-throughput workflow that exactly detects the inhibition of DNA-to-RNA transcription.
That’s achieved by combining two successive deep convolutional neural networks, allowing (1) to robotically detect cell nuclei (thus enabling monitoring of cell dying) and (2) to classify the extracted nuclear pictures in a binary vogue. This analytical pipeline is R-based and is likely to be merely utilized to any microscopic platform.
 DNA / RNA Damage Antibody |
|
abx442850-100ug |
Abbexa |
100 ug |
EUR 551 |
|
|
DNA / RNA Damage Antibody |
|
abx443130-100ug |
Abbexa |
100 ug |
EUR 551 |
|
|
DNA / RNA Damage Antibody |
|
abx443410-100ug |
Abbexa |
100 ug |
EUR 537 |
|
|
DNA / RNA Damage Antibody |
|
abx443691-100ug |
Abbexa |
100 ug |
EUR 565 |
|
|
DNA / RNA Damage Antibody |
|
abx443972-100ug |
Abbexa |
100 ug |
EUR 551 |
|
|
DNA / RNA Damage Antibody |
|
abx444253-100ug |
Abbexa |
100 ug |
EUR 551 |
|
|
DNA / RNA Damage Antibody |
|
abx444534-100ug |
Abbexa |
100 ug |
EUR 551 |
|
|
DNA / RNA Damage Antibody |
|
20-abx444884 |
Abbexa |
|
|
|
|
 Antibody (ATTO 565)) Mediator Of DNA Damage Checkpoint 1 (MDC1) Antibody (ATTO 565) |
|
abx440635-100ug |
Abbexa |
100 ug |
EUR 551 |
|
|
 WSE-6301 Luminograph III Basic/ PC contorl system |
|
Atto-0001 |
Atto |
1unit |
EUR 15760 |
|
Description: 6.0mega Pi xel Cool ed CCD wi r h F0.8 |
 Monoclonal antibody for DNA/RNA Damage |
|
SMC-155C |
Stressmarq |
0.025mg |
EUR 190 |
|
|
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated. |
Monoclonal antibody for DNA/RNA Damage |
|
SMC-155D |
Stressmarq |
0.1mg |
EUR 332 |
|
|
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated. |
Monoclonal antibody for DNA/RNA Damage |
|
SMC-155D-A390 |
Stressmarq |
0.1mg |
EUR 379 |
|
|
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 390. |
Monoclonal antibody for DNA/RNA Damage |
|
SMC-155D-A488 |
Stressmarq |
0.1mg |
EUR 378 |
|
|
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 488. |
Monoclonal antibody for DNA/RNA Damage |
|
SMC-155D-A565 |
Stressmarq |
0.1mg |
EUR 378 |
|
|
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 565. |
Monoclonal antibody for DNA/RNA Damage |
|
SMC-155D-A594 |
Stressmarq |
0.1mg |
EUR 378 |
|
|
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 594. |
Monoclonal antibody for DNA/RNA Damage |
|
SMC-155D-A633 |
Stressmarq |
0.1mg |
EUR 378 |
|
|
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 633. |
Monoclonal antibody for DNA/RNA Damage |
|
SMC-155D-A655 |
Stressmarq |
0.1mg |
EUR 378 |
|
|
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 655. |
Monoclonal antibody for DNA/RNA Damage |
|
SMC-155D-A680 |
Stressmarq |
0.1mg |
EUR 378 |
|
|
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 680. |
Monoclonal antibody for DNA/RNA Damage |
|
SMC-155D-A700 |
Stressmarq |
0.1mg |
EUR 378 |
|
|
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 700. |
Monoclonal antibody for DNA/RNA Damage |
|
SMC-155D-ALP |
Stressmarq |
0.1mg |
EUR 372 |
|
|
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Alkaline Phosphatase. |
Monoclonal antibody for DNA/RNA Damage |
|
SMC-155D-APC |
Stressmarq |
0.1mg |
EUR 377 |
|
|
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with APC. |
Monoclonal antibody for DNA/RNA Damage |
|
SMC-155D-APCCY7 |
Stressmarq |
0.1mg |
EUR 450 |
|
|
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with APC/Cy7. |
Monoclonal antibody for DNA/RNA Damage |
|
SMC-155D-BI |
Stressmarq |
0.1mg |
EUR 374 |
|
|
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Biotin. |
Monoclonal antibody for DNA/RNA Damage |
|
SMC-155D-DY350 |
Stressmarq |
0.1mg |
EUR 393 |
|
|
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 350. |
Monoclonal antibody for DNA/RNA Damage |
|
SMC-155D-DY405 |
Stressmarq |
0.1mg |
EUR 381 |
|
|
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 405. |
Monoclonal antibody for DNA/RNA Damage |
|
SMC-155D-DY488 |
Stressmarq |
0.1mg |
EUR 371 |
|
|
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 488. |
Monoclonal antibody for DNA/RNA Damage |
|
SMC-155D-DY594 |
Stressmarq |
0.1mg |
EUR 373 |
|
|
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 594. |
Monoclonal antibody for DNA/RNA Damage |
|
SMC-155D-DY633 |
Stressmarq |
0.1mg |
EUR 368 |
|
|
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 633. |
Monoclonal antibody for DNA/RNA Damage |
|
SMC-155D-FITC |
Stressmarq |
0.1mg |
EUR 370 |
|
|
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with FITC. |
Monoclonal antibody for DNA/RNA Damage |
|
SMC-155D-HRP |
Stressmarq |
0.1mg |
EUR 366 |
|
|
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with HRP. |
Monoclonal antibody for DNA/RNA Damage |
|
SMC-155D-P594 |
Stressmarq |
0.1mg |
EUR 385 |
|
|
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with PE/ATTO 594. |
Monoclonal antibody for DNA/RNA Damage |
|
SMC-155D-PCP |
Stressmarq |
0.1mg |
EUR 377 |
|
|
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with PerCP. |
Monoclonal antibody for DNA/RNA Damage |
|
SMC-155D-RPE |
Stressmarq |
0.1mg |
EUR 375 |
|
|
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with RPE. |
Monoclonal antibody for DNA/RNA Damage |
|
SMC-155D-STR |
Stressmarq |
0.1mg |
EUR 376 |
|
|
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Streptavidin. |
Monoclonal antibody for DNA/RNA Damage |
|
SMC-155S |
Stressmarq |
0.012mg |
EUR 65 |
|
|
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated. |
 Antibody (ATTO 565)) DNA Methyltransferase 1 (DNMT1) Antibody (ATTO 565) |
|
abx440637-100ug |
Abbexa |
100 ug |
EUR 578 |
|
|
DNA Methyltransferase 1 (DNMT1) Antibody (ATTO 565) |
|
abx440647-100ug |
Abbexa |
100 ug |
EUR 565 |
|
|
DNA Methyltransferase 1 (DNMT1) Antibody (ATTO 565) |
|
abx444785-100ug |
Abbexa |
100 ug |
EUR 578 |
|
|
 Antibody (ATTO 565)) DNA Methyltransferase 3 Like (Dnmt3L) Antibody (ATTO 565) |
|
abx440705-100ug |
Abbexa |
100 ug |
EUR 578 |
|
|
) Phosphoserine Antibody (ATTO 565) |
|
abx448303-400ul |
Abbexa |
400 ul |
EUR 592 |
|
|
) Phosphothreonine Antibody (ATTO 565) |
|
abx448304-400ul |
Abbexa |
400 ul |
EUR 592 |
|
|
) Phosphotyrosine Antibody (ATTO 565) |
|
abx448418-400ul |
Abbexa |
400 ul |
EUR 592 |
|
|
) Crotonaldehyde Antibody (ATTO 565) |
|
abx448591-100ug |
Abbexa |
100 ug |
EUR 704 |
|
|
Crotonaldehyde Antibody (ATTO 565) |
|
abx448609-100ug |
Abbexa |
100 ug |
EUR 704 |
|
|
) KDEL Antibody (ATTO 565) |
|
abx448663-100ug |
Abbexa |
100 ug |
EUR 606 |
|
|
KDEL Antibody (ATTO 565) |
|
abx448681-100ug |
Abbexa |
100 ug |
EUR 606 |
|
|
KDEL Antibody (ATTO 565) |
|
abx448699-100ug |
Abbexa |
100 ug |
EUR 606 |
|
|
) GRP94 Antibody (ATTO 565) |
|
abx448717-100ug |
Abbexa |
100 ug |
EUR 606 |
|
|
) Ubiquitin Antibody (ATTO 565) |
|
abx448825-100ug |
Abbexa |
100 ug |
EUR 662 |
|
|
Ubiquitin Antibody (ATTO 565) |
|
abx448843-100ug |
Abbexa |
100 ug |
EUR 662 |
|
|
) GST Antibody (ATTO 565) |
|
abx448861-100ug |
Abbexa |
100 ug |
EUR 606 |
|
|
Ubiquitin Antibody (ATTO 565) |
|
abx448879-100ug |
Abbexa |
100 ug |
EUR 662 |
|
|
) Metallothionein Antibody (ATTO 565) |
|
abx448897-100ug |
Abbexa |
100 ug |
EUR 606 |
|
|
Metallothionein Antibody (ATTO 565) |
|
abx448915-100ug |
Abbexa |
100 ug |
EUR 606 |
|
|
Metallothionein Antibody (ATTO 565) |
|
abx448933-100ug |
Abbexa |
100 ug |
EUR 606 |
|
|
) Tbj51 Antibody (ATTO 565) |
|
abx448969-100ug |
Abbexa |
100 ug |
EUR 606 |
|
|
) TbHsp70 Antibody (ATTO 565) |
|
abx448987-100ug |
Abbexa |
100 ug |
EUR 606 |
|
|
) CBP Antibody (ATTO 565) |
|
abx449059-100ug |
Abbexa |
100 ug |
EUR 606 |
|
|
CBP Antibody (ATTO 565) |
|
abx449077-100ug |
Abbexa |
100 ug |
EUR 606 |
|
|
) SMAD3 Antibody (ATTO 565) |
|
abx449113-100ug |
Abbexa |
100 ug |
EUR 606 |
|
|
) SFRP1 Antibody (ATTO 565) |
|
abx449311-100ug |
Abbexa |
100 ug |
EUR 606 |
|
|
) PDGFB Antibody (ATTO 565) |
|
abx449401-100ug |
Abbexa |
100 ug |
EUR 606 |
|
|
) BAD Antibody (ATTO 565) |
|
abx449455-100ug |
Abbexa |
100 ug |
EUR 606 |
|
|
BAD Antibody (ATTO 565) |
|
abx449473-100ug |
Abbexa |
100 ug |
EUR 606 |
|
|
) CDKN2A Antibody (ATTO 565) |
|
abx449491-100ug |
Abbexa |
100 ug |
EUR 606 |
|
|
) MEK1 Antibody (ATTO 565) |
|
abx449563-100ug |
Abbexa |
100 ug |
EUR 606 |
|
|
) 4EBP1 Antibody (ATTO 565) |
|
abx449599-100ug |
Abbexa |
100 ug |
EUR 606 |
|
|
) LRP1 Antibody (ATTO 565) |
|
abx449653-100ug |
Abbexa |
100 ug |
EUR 606 |
|
|
LRP1 Antibody (ATTO 565) |
|
abx449671-100ug |
Abbexa |
100 ug |
EUR 606 |
|
|
) SFRP2 Antibody (ATTO 565) |
|
abx449689-100ug |
Abbexa |
100 ug |
EUR 606 |
|
|
) DKK1 Antibody (ATTO 565) |
|
abx449707-100ug |
Abbexa |
100 ug |
EUR 606 |
|
|
) FOXO1 Antibody (ATTO 565) |
|
abx449761-100ug |
Abbexa |
100 ug |
EUR 606 |
|
|
PDGFB Antibody (ATTO 565) |
|
abx449797-100ug |
Abbexa |
100 ug |
EUR 606 |
|
|
) Palladin Antibody (ATTO 565) |
|
abx449851-100ug |
Abbexa |
100 ug |
EUR 606 |
|
|
) RICTOR Antibody (ATTO 565) |
|
abx449887-100ug |
Abbexa |
100 ug |
EUR 606 |
|
|
) Kir4.1 Antibody (ATTO 565) |
|
abx445823-100ug |
Abbexa |
100 ug |
EUR 578 |
|
|
 Antibody (ATTO 565)) QKI, KH Domain Containing RNA Binding (QKI) Antibody (ATTO 565) |
|
abx440787-100ug |
Abbexa |
100 ug |
EUR 578 |
|
|
 Antibody (ATTO 390)) Mediator Of DNA Damage Checkpoint 1 (MDC1) Antibody (ATTO 390) |
|
abx440073-100ug |
Abbexa |
100 ug |
EUR 551 |
|
|
 Antibody (ATTO 488)) Mediator Of DNA Damage Checkpoint 1 (MDC1) Antibody (ATTO 488) |
|
abx440354-100ug |
Abbexa |
100 ug |
EUR 551 |
|
|
 Antibody (ATTO 594)) Mediator Of DNA Damage Checkpoint 1 (MDC1) Antibody (ATTO 594) |
|
abx440916-100ug |
Abbexa |
100 ug |
EUR 551 |
|
|
 Antibody (ATTO 633)) Mediator Of DNA Damage Checkpoint 1 (MDC1) Antibody (ATTO 633) |
|
abx441197-100ug |
Abbexa |
100 ug |
EUR 551 |
|
|
 Antibody (ATTO 655)) Mediator Of DNA Damage Checkpoint 1 (MDC1) Antibody (ATTO 655) |
|
abx441478-100ug |
Abbexa |
100 ug |
EUR 551 |
|
|
 Antibody (ATTO 680)) Mediator Of DNA Damage Checkpoint 1 (MDC1) Antibody (ATTO 680) |
|
abx441759-100ug |
Abbexa |
100 ug |
EUR 551 |
|
|
 Antibody (ATTO 700)) Mediator Of DNA Damage Checkpoint 1 (MDC1) Antibody (ATTO 700) |
|
abx442040-100ug |
Abbexa |
100 ug |
EUR 551 |
|
|
 WSC-2400 SeesawShaker atto |
|
2312200 |
Atto |
1unit |
EUR 995 |
 Antibody (ATTO 565)) Endoplasmin (GRP94) Antibody (ATTO 565) |
|
abx440564-200ug |
Abbexa |
200 ug |
EUR 592 |
|
|
 Antibody (ATTO 565)) GRP75 (Grp75) Antibody (ATTO 565) |
|
abx440584-100ug |
Abbexa |
100 ug |
EUR 578 |
|
|
 Antibody (ATTO 565)) ubiquitin (Ubiquitin) Antibody (ATTO 565) |
|
abx440605-200ug |
Abbexa |
200 ug |
EUR 634 |
|
|
ubiquitin (Ubiquitin) Antibody (ATTO 565) |
|
abx440614-200ug |
Abbexa |
200 ug |
EUR 634 |
|
|
